The effect of Lyophilization technique on the stability and durability of protein molecule: A Review

Lyophilization is the process where moisture is removed from the perishable material and helps in extending their shed life and making the substance more portable. Lyophilization is otherwise called Crystallisation, used in the pharmaceutical industry to increase the stability and shelf life of the pharmaceutical industry. The Lyophilization of protein is removing the moisture from it, so that it could be stored for a longer period of time. The potency of frozen protein products is far greater than that of liquid formulations. The primary consideration during lyophilization is the long durability of protein compositions, which is correlated with water content. Small-molecule pharmaceuticals can typically be formulated without the addition of additives, or simply by adding a bulking agent or pH modifier to produce a liquid formulation that is rigid enough to withstand the time required before it can be freeze-dried. The primary consideration during lyophilization is the long durability of protein compositions, which is correlated with water content. Small-molecule pharmaceuticals can typically be formulated without the addition of additives, or simply by adding a bulking agent or pH modifier to produce a liquid formulation that is rigid enough to withstand the time required before it can be freeze-dried. The paper reviews different articles and journals to provide a critical analysis of the process of Lyophilization of protein and discuss its detailed process. The paper would review the strength and limitations of the Lyophilization process.

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Graphene based Solar cells and superior energy conversion

Among the renewable energy generation methods, the most interesting one is the photovoltaic energy technology, which has unlimited usage potential and generates electricity by using renewable sunlight. Solar cells are a secure and viable photoelectric technology that could substitute existing fossil fuel systems. Graphene, with its outstanding electrical and optical properties, mechanical flexibility, adjustable working function, attracts great interest among scientific research groups in many fields. It has been identified as an exceptional material for upcoming energy storage devices. This review examines a few features of graphenes and evaluates whether it is a feasible alternative to the traditional materials used in photovoltaic cells.

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Density functional theory used for the study of molecular interaction in water cluster: A review

Due to the significance of “water clusters,” groups of water molecules locked together by hydrogen bonds, in understanding cloud and ice formation, solution chemistry, and a wide range of biological activities, they have been the focus of several intensive experimental and theoretical research. There is an obvious need for chemists to have a better knowledge of how such aggregates affect the general structure of their surrounds. “Water clusters” can play a significant role in the stability of supramolecular systems both in solution and in the solid state.

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A quantum mechanical study of gallium clusters: Review

Superatoms have being researched because they could replace other elements. Superatom availability has drawn attention to the solution-phase synthesis of superatoms. The preceding method, however, is essentially restricted to the development of a single cluster. Here, superatoms are studied, and the presence of different numbers of gallium atoms is designed to alter the amount of valence electrons in these superatoms. Clusters of 3, 12, 13, and various numbers of atoms have been manufactured using the dendrimer template approach. Ga13 is structurally and electrochemically observed to be entirely distinct from the other clusters due to its halogen-like superatomic composition. The reactivities of the 13 and 3 atom gallium clusters, which may fill the 2P and 1P superatomic orbitals, respectively, vary. 

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Analysis of Macrotyloma uniflorum Lam. (kulthi) seed germination rate under ZnCl2 stress

Macrotyloma uniflorum Lam. (kulthi) highly widespread form of legume crop that is frequently seen in southern India is a member of the Fabaceae family. Carotene, Thiamine, Riboflavin, Niacin, Vitamin C, and minerals are abundantly found in Macrotyloma uniflorum. Antibacterial, antimicrobial, and antioxidant capabilities of Macrotyloma uniflorum nourish the skin and lessen recurrent skin infections. The current study intends to demonstrate the major impact of ZnCl2 on seed germination of M. uniflorum. Morphological parameters, including as shoot length, root length, and fresh weight, were also examined after germination. Different concentrations of ZnCl2 (2%–10%) were applied to healthy, young seeds. The impact of metal stress (ZnCl2) on the germination of Macrotyloma uniflorum seeds, outcomes of seeds treated with ZnCl2 and untreated seeds were contrasted. The largest percentage of seed germination 80% is seen at 4% zinc chloride concentration, while the lowest 30% is seen at 10% zinc chloride concentration. While the highest shoot length and root length, respectively, are found at 4% concentration of ZnCl2.

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Review: Ionic Liquid Crystal

This Review discusses current advancements in thermotropic ionic liquid crystal design, synthesis, characterization, and application from 2005 to 2015. It was created to provide a thorough review of the “state-of-the-art” in the industry. Low molar mass and dendrimeric thermotropic ionic mesogens, as well as a few metal-containing compounds are the main topics of study. However, there will also be some references to lyotropic or polymeric ionic liquid crystals, and more specifically, to ionic liquids. The focus will be on liquid-crystalline materials made up of organic cations and inorganic/organic anions that are not covalently bonded but interact via electrostatic and other noncovalent interactions, but mesoionic and zwitterionic mesogens are also discussed to some extent.

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Numerical view of Lucas-Lehmer polynomials with its characteristics

This chapter presents Lucas-Lehmer polynomials and its shifted form which make a series of orthogonal polynomials. The orthogonal polynomials have a big contribution in the approximation theory. We discuss and prove various essential aspects of Lucas-Lehmer polynomials such as the orthogonality, recursive relation and Parseval’s identity. The operational matrix of derivative and integral for LLP is also constructed.

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Ageratum spp: An excellent therapeutic medicinal plant

Ageratum spp. are medicinal weed plant. Two varieties Ageratum houstonianum Mill and Ageratum   conyzoides   are   very common   and   using   in   the   medicinal   field. Ageratum houstonianum Mill plant is ubiquitously found in every continent of the world. It is commonly known as Blue mink. Whereas Ageratum conyzoides Mill. is commonly known as blue billygoatweed and jungali pudina or appa grash in hindi. In India these are found everywhere in the tropical region. This weed plant have several medicinal properties such as antioxidant, phenolics, flavonoids, anti-diabetic, antimicrobial etc. The bioactive compounds of Ageratum Mill plants commercially used to treat several health problems such as wound healing. Recently blue mink has been screened for its antimicrobial and mosquitocidal activities. In this review authors have tried to summarize the bioactive compounds of medicinal values from the Ageratum spp. and their medicinal uses for human welfare.

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ODE Based Modeling of Drug Concentrations in Human Bloodstream

In the last few years, mathematician & Scientist used numerous scientific studies to model the real-world problems related in the field of pharmacology or pharmaceutical sciences. In this paper we emphasis on the mathematical modeling of drug concentration in human blood stream. For this we formulate ordinary differential equation (ODE) based two models, in which first model is compartment model and second is the modified model when multiple drug doses are given to a patient at a regular time interval gap. For the solution of models we use some mathematical techniques like, Laplace transformation, delta function, Step function and interpreted the resultant equation of model from which we can evaluate the drug amount in human blood stream at any time t.

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Review on nanotechnology based metallic compound

The study of nanotechnology has the potential to fundamentally alter how humans perceive and influence change in a variety of fields, including mass transfer, biomedicine, agriculture, and water management, among others. The word “Nano” refers to a type of technology that uses tiny particles that can be seen with the naked eye. Working at this size enables more successful creative solutions to special situations. For instance, employing zeolites and nanoclays to improve soil fertility and quality can increase fertiliser effectiveness. The development of intelligent seeds coated with nano-polymers and timed for germination under favourable conditions seems promising. Crops are often categorised according to their nutrient needs when precision farming inputs are used, and with the help of a Nano-biosensor and a satellite system, the distribution of nutrients may be tracked more precisely than with current techniques. This also highlights the creation of nano-herbicides to deal with weed control. Studies exist that show how efficient nano-fertilizers are in increasing the productivity and efficiency of the nutrients, lowering soli toxicity, and reducing potential contamination-related problems. Therefore, nanotechnology has great promise for sustainable agriculture, particularly in underdeveloped nations.

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Assessment of Heavy Metal Contamination in Soil: A Review

Abstract: Metal contamination in soil is a major problem growing rapidly now-a-days due to industrialization and human activities such as mining, smelting and electroplating. Metals above their permissible limit are dangerous due to high toxicity as they affect human and animal health. The high amount of these metals in soil is unacceptable for the cultivation of crops due to the risk of bioaccumulation and biomagnifications in the food chain. Thus, indirectly affect human health. Furthermore, decreased soil microorganism activity is also due to the presence of high amount of metal in soil as a result soil quality decreased. Thus, presence of high amount of metal in soil is one of the major environmental factors which influences many aspects of human life. Therefore, in light of above this study is an attempt to assessing the heavy metaleffects in soiland its consequences.

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